Prioritizing genomic drug targets in pathogens
نویسندگان
چکیده
منابع مشابه
Prioritizing Genomic Drug Targets in Pathogens: Application to Mycobacterium tuberculosis
We have developed a software program that weights and integrates specific properties on the genes in a pathogen so that they may be ranked as drug targets. We applied this software to produce three prioritized drug target lists for Mycobacterium tuberculosis, the causative agent of tuberculosis, a disease for which a new drug is desperately needed. Each list is based on an individual criterion....
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Emergence of drug resistance is a major threat to public health. Many pathogens have developed resistance to most of the existing antibiotics, and multidrug-resistant and extensively drug resistant strains are extremely difficult to treat. This has resulted in an urgent need for novel drugs. We describe a database called 'Database of Drug Targets for Resistant Pathogens' (DDTRP). The database c...
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Biological pathways information has accumulated along with Genomic sequence data. These metabolic pathways help us in understanding network robustness and complex reaction networks. They also provide a framework for improved understanding of microbial physiology and for antimicrobial drug discovery. This article is an attempt to understand the local and global properties of metabolic networks i...
متن کاملPrioritizing pathogens for potential future regulation in drinking water.
A method alternative to the EPA’s determination of microorganisms of regulatory concern for drinking water quality is proposed. Drinking water in the U.S. is among the safest in the world but outbreaks of disease linked to drinking water still occur. For example, from 1991 to 2002 there were 183 reported waterborne disease outbreaks caused by chemical contaminants (16%), viruses (8%), bacteria ...
متن کاملIdentification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach
BACKGROUND The increased sequencing of pathogen genomes and the subsequent availability of genome-scale functional datasets are expected to guide the experimental work necessary for target-based drug discovery. However, a major bottleneck in this has been the difficulty of capturing and integrating relevant information in an easily accessible format for identifying and prioritizing potential ta...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2005
ISSN: 1553-734X,1553-7358
DOI: 10.1371/journal.pcbi.0020061.eor